Non-target metabolomics is an unbiased metabolomic analysis that enables the discovery of new biomarkers or the discovery of differential metabolites for a comprehensive and systematic analysis of endogenous metabolites in an organism. Non-target metabolomics can detect a large number of metabolite signals simultaneously, but its sensitivity and qualitative quantification accuracy are poor. According to the different detection platforms, it can be subdivided into LC-MS non-target metabolomics and GC-MS non-target metabolomics.